INDIA'S 3rd GENARATION TECHNOLOGY: September 2009

2009/09/14 at 10:30 PM | 0 comments

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2009/09/10 at 11:55 PM | 0 comments

One Vaccine Shot Seen as Protective for Swine Flu
Defying the expectations of experts, clinical trials are showing that the new H1N1 swine flu vaccine protects with only one dose instead of two, so the vaccine supplies now being made will go twice as far as had been predicted.
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Times Topics: Swine Flu (AH1N1 Virus)
That means it should be possible to vaccinate — well before the flu’s expected midwinter peak — all the 159 million people that the Centers for Disease Control and Prevention estimate are in the high-risk groups: pregnant women, people under 24 years old or caring for infants, people with high-risk medical conditions and health-care workers.
Barring production delays, the government hopes to have in hand 195 million doses by year’s end.
The first convincing trial results from a single 15-microgram dose in adults were published online Thursday afternoon by The New England Journal of Medicine. That trial was done in Australia, but the vaccine maker, CSL Limited, is under contract to supply millions of doses to the United States government, and the president of the company’s American subsidiary said he expected its trials here to have similar results.
The H1N1 swine flu pandemic has now reached 168 countries. It arrived in the United States late in the spring and infected more than one million people. It did not fade out as seasonal flu does, but persisted, especially in summer camps. Nearly 600 people had died by the end of August, according to the disease control agency.
Cases are now surging again, especially in the Southeast where many schools and universities reopen earlier than in the rest of the country.
Dr. Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, said trials now under way under the sponsorship of the National Institutes of Health were showing that adults who got only a single dose were protected within 8 to 10 days, which he said “corroborates and confirms the exciting data” reported in the Australian study.
Robust protection produced so quickly in high-risk groups means lives will presumably be saved, Dr. Fauci said.
Costs will also be lowered by having a more efficient vaccine, he said, “but I can’t give you a dollar figure.”
Also, more vaccine could be available to poor countries that were largely left out of last spring’s global scramble to sign vaccine makers to contracts. Experts have worried that rich countries would be protected this winter while poor ones — where people are more likely to die because of drug shortages and substandard hospital care — would bear the brunt of the pandemic.
“This is definitely a big deal,” said Dr. John J. Treanor, a vaccine expert at the University of Rochester. “People had been planning for a scenario that would require two doses.”
“This will take the edge off the nail-biting,” Dr. Treanor added.
The results released Thursday were based on the first three weeks of a clinical trial. Healthy adults got one 15-microgram shot, and their blood was tested 21 days later. By that time, 97 percent of the 120 adults had enough antibodies to be considered protected. Another group that got 30-microgram doses had no greater protection.
There were no deaths or dangerous side-effects. Almost half of the participants reported sore arms or headaches, but that is normal with flu shots.
The American trials began about two weeks later, said Paul R. Perreault, president of CSL Biotherapies, the company’s American subsidiary. “My experience with this tells me they shouldn’t be any different,” Mr. Perreault said.
Dr. Fauci said he would discuss the details of the N.I.H. trials at a news conference on Friday afternoon.
Seasonal flu shots are available now, and Federal officials are urging Americans to get one. Little or no swine flu vaccine will be available before late October. There have been no clinical trials of giving both shots at the same time, and Federal health officials have issued no recommendations on that.
Experts had predicted for months that, because the H1N1 swine flu has never been seen before by human immune systems, it would take two doses, administered weeks apart, to get a “take” — antibody levels as high as those produced by regular flu shots.
The authors of the Australian study said the robust response implied that there was some previously unsuspected crossover protection from having had previous strains of H1N1 seasonal flus or from the H1N1 components of seasonal flu shots.
In mid-August, a Chinese vaccine maker, Sinovac Biotech, also reported that one shot of its vaccine gave protection against the flu. But because it released no data about the size of the dose or the composition of its vaccine, it was impossible for American experts to evaluate the claim.
Also, none of the 10 Chinese companies producing swine flu vaccine have licenses to sell in the United States, as CSL does, so their vaccines would have virtually no impact on the spread of the disease here.
Although the Australian trial was in healthy adults only, Dr. Treanor said he believed one dose of the new vaccine would prove effective in everyone from age 9 and up.
Pediatricians usually give two shots to children ages 6 months to 9 years who have never had a flu shot; the first primes the immune system and subsequent shots act as boosters that create new surges of antibodies, though slightly varied each year as strains mutate.
Infants under 6 months old are not normally given flu shots. Pregnant women are, and babies can inherit some temporary immunity from their mothers

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HOW TO PREVENT FROM SWINE FLUE

at 11:36 PM | 0 comments

Already, there are reports coming from schools across Florida that kids are being diagnosed with swine flu (also known as the H1N1 virus). And in Georgia, Alaska and Puerto Rico, health officials say swine flu already is widespread.The good news is this: Although swine flu is highly contagious, the World Health Organization says it generally causes "very mild illness" in healthy people.But there are ways to prevent the flu from spreading, mainly by washing your hands.If doctors sound like your mom, who keeps bugging you to wash your hands before you eat, there's a reason."Whenever you're contaminated by touching things that other people have touched — desks or tabletops in the lunchroom — you really should wash your hands before eating or drinking or touching your face," said Dr. Philip Tierno, director of clinical microbiology and immunology at New York University's Langone Medical Center. Eighty percent of all infections are spread when you touch germs and then touch your mouth, eyes and nose.And the flu bug is a survivor. The swine-flu virus can survive on a desk or a doorknob for two to eight hours after it lands there, according to the U.S. Centers for Disease Control and Prevention. That's why hand-washing — and disinfecting lunchroom tables, doorknobs and gym equipment — is so important.However, many kids are bound to get swine flu this year. So here's some advice from the CDC: If you think you're sick, stay home. The symptoms of swine flu include fever, cough, sore throat, runny or stuffy nose, body aches, headache, chills and fatigue. A significant number of those already afflicted also have reported diarrhea and vomiting.Wash handsWash your hands frequently with soap and water. But not so fast, kiddo! You're supposed to wash for 20 seconds — so sing the "Happy Birthday" song to yourself twice to make sure you've washed long enough. And don't just wash your palms. Rub soap on the backs of your hands, between your fingers and underneath your fingernails. Antibacterial soap or plain soap? There's no need to use antibacterial soap — the water washes away the flu virus.Hand Sanitizer 101If soap and water are not available, use hand-sanitizing gel. Pick a brand that contains at least 62percent alcohol, said Tierno, the microbiologist. Most important: Wash hands or use hand sanitizer right before you eat lunch — because when you pick up your sandwich, you could spread germs from your hands to your food and then to your mouth.Coughing and sneezing etiquetteCough or sneeze into a tissue — and then wash or sanitize your hands. If you don't have a tissue handy, sneeze or cough into the crook of your arm or your shoulder — so your germs don't spread through the air. Don't cough or sneeze into your hands! If you do, wash immediately.Don't touch!Avoid touching your eyes, nose and mouth. That's the fastest way to spread germs into your body.Water-fountain phobia?The danger from the water fountain isn't from kids putting their mouths on the fountain — because the stream of water washes away germs. The most contaminated part of the fountain is the handle or button you push to turn it on, say experts. But to be safe during the swine- flu pandemic, it's probably best to send kids to school with their own water bottles. What about handrails, doorknobs or keyboards? It's not practical to ask kids not to touch any surfaces at school. Instead, experts recommend that kids carry their own container of hand sanitizer and use it frequently

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INDIA'S 3rd GENARATION TECHNOLOGY

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